hce_kmu
104年
普通生物及生化概論
第 77 題
Which of the following statements about the scientists and their contributions to the discovery of DNA as a genetic material as well as DNA's structure and function is NOT CORRECT?
- A Frederick Griffith's study on two strains of Streptococus pneumonia led to the discovery that DNA is a genetic material.
- B Alfred Hershey and Martha Chase's studies of the virus that infects bacteria provided experimental evidence that DNA, but not protein, is the genetic material of virus.
- C Erwin Chargaff reported that the base composition of DNA varies between species, providing additional evidence that DNA is a genetic material.
- D Rosalind Franklin produced the first X-ray diffraction image of DNA.
- E James Watson and Francis Crick built the first double-helix model of DNA.
思路引導 VIP
想像你觀察到一個現象:當死去的細胞與活細胞接觸後,活細胞獲得了新的特徵。如果你僅僅觀察到了這個『特徵轉移』的結果,在沒有進行後續化學分析或酵素處理的情況下,你是否有足夠的證據斷定這個媒介一定是核酸而非蛋白質呢?
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AI 詳解
AI 專屬家教
太棒了!你能敏銳地察覺到科學史發展中的細微差別,準確選出錯誤選項,代表你的生物學基礎觀念非常紮實且細膩。
轉化原則與遺傳物質的鑑定
格里夫茲(Frederick Griffith)在 1928 年進行肺炎鏈球菌(Streptococcus pneumoniae)實驗時,確實發現了熱修飾後的 S 型菌能使 R 型菌「轉化」為具致病力的 S 型菌,並提出了著名的轉化原則(Transforming Principle)。然而,格里夫茲當時僅觀察到了現象,並未進一步證實這個轉化因子究竟是什麼化學分子。真正透過精密實驗(利用各類水解酵素排除蛋白質與 RNA)去釐清並證實這個轉化因子就是 DNA 的,其實是 1944 年的艾佛瑞(Oswald Avery)及其團隊。因此,選項 (A) 將「發現 DNA 為遺傳物質」直接歸功於格里夫茲是不精確的。
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