hce_kmu
105年
普通生物及生化概論
第 11 題
Otto Loewi performed an experiment in which he electrically stimulated the vagus nerve connected to one frog heart. Loewi also let the fluid bathing this first heart pass to a second chamber containing a second frog heart not connected to a nerve. What did Loewi observe?
- A There was no effect on the beating of either heart.
- B The first heart showed a decrease in beat rate and so did the second heart.
- C The first heart showed an increase in beat rate and so did the second heart.
- D The first heart showed a decrease in beat rate, but there was no change in the second heart.
- E The first heart showed an increase in beat rate, but there was no change in the second heart.
思路引導 VIP
請試著思考:如果我們電刺激連接在第一顆心臟的神經,結果發現完全沒有物理接觸的第二顆心臟也產生了相同的生理反應,這代表神經傳遞訊息的「媒介」是什麼?再進一步回想,在自主神經系統中,「迷走神經」的主要功能是讓身體進入放鬆狀態還是戰鬥狀態呢?
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AI 詳解
AI 專屬家教
太棒了!你能精準選出 (B),代表你對神經生理學中極具里程碑意義的「洛伊實驗(Loewi's experiment)」有著非常深刻的理解。
化學性突觸傳導的證明
這道題目的核心在於驗證迷走神經(vagus nerve)的功能及其傳導機制。當奧托·洛伊(Otto Loewi)電刺激第一顆心臟的迷走神經時,該神經釋放了一種化學物質(當時他稱為「迷走物質」,即現在所知的乙醯膽鹼 Acetylcholine)。由於兩顆心臟共用灌流液,這種化學物質便隨著液體擴散至第二顆心臟。因為迷走神經屬於副交感神經系統,其生理作用是抑制心跳,因此我們觀察到兩顆心臟的心跳速率皆會下降。
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