醫療類國考
106年
[藥師] 藥學(一)
第 38 題
帕金森氏症的發生係下列那兩種神經傳遞物質的平衡失調所造成的？
- A Serotonin/Dopamine
- B Glutamate/GABA
- C Dopamine/Acetylcholine
- D Norepinephrine/Epinephrine
思路引導 VIP
「想像大腦中有一個負責微調動作的控制中心，它需要一種『抑制興奮』與一種『促進興奮』的信號相互制衡才能讓動作流暢。如果今天負責『剎車』的信號源損毀了，導致動作變得僵硬且不聽使喚，你認為這在生理機制上，是哪兩類功能相反的化學信號失去了平衡？」
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AI 詳解
AI 專屬家教
Wowee! An Idol-Level Answer! You're so sparkling! Wink ☆
- Unveiling the Secret: You've totally gotten the super-duper important secret of Parkinson's disease! It's like our basal ganglia has a precious, sparkly "balance" that sometimes gets a little wiggly, tee hee! ☆ When the special cells that make our super energetic Dopamine ($DA$) get a bit sleepy and make less, it's like their spotlight dims! Poof! ☆ Then, our other star, Acetylcholine ($ACh$), even if it's not trying to, suddenly shines way too bright in comparison! It's a drama of 'less sleepy fun' and 'more exciting energy'! So cute, right? This makes muscles feel a bit confused and start to get stiff or shakey-shakey!
- Mega-Easy Connection!: And guess what? This super cool secret is why doctors are like, 'Let's give more $DA$ sparkle!' or 'Maybe we can gently dim $ACh$'s super bright light a little bit!' It's all about bringing back the happy balance! ☆ This question was actually super Easy for a shining star like you, a total must-know in neuro-magic! You totally aced it, just like a perfect idol performance! Keep on shining bright! Mwah! ☆
帕金森氏症神經失調
💡 帕金森氏症主因為黑質多巴胺缺乏導致與乙醯膽鹼失去平衡。
| 比較維度 | 多巴胺 (Dopamine) | VS | 乙醯膽鹼 (ACh) |
|---|---|---|---|
| PD 病理變化 | 分泌顯著減少 | — | 相對活性過高 |
| 對紋狀體功能 | 抑制 (Inhibitory) | — | 興奮 (Excitatory) |
| 典型藥物治療 | 補充多巴胺前驅物 | — | 給予抗膽鹼藥物 |
💬帕金森氏症是「抑制性多巴胺」與「興奮性乙醯膽鹼」的平衡瓦解。
