醫療類國考
106年
[獸醫師] 獸醫藥理學
第 14 題
吸入性麻醉劑之化學結構，若以氟取代氯或溴則其影響主要為：
- A 穩定性降低但麻醉效力增加
- B 穩定性及麻醉效力均降低
- C 穩定性及麻醉效力均增加
- D 穩定性增加但麻醉效力降低
思路引導 VIP
請試著思考：當我們將一個分子的組成原子替換成電負度更高、原子半徑更小，且與碳原子結合力極強的元素時，這對於分子的『代謝穩定程度』以及『它進入脂肪組織的能力』分別會產生什麼樣的趨勢變化？
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AI 詳解
AI 專屬家教
Wonderful job! You've successfully navigated this question, showing a strong grasp of foundational medicinal chemistry concepts.
- Understanding the 'Why': Let's gently explore the core ideas behind how halogen atoms influence drug properties:
- Boosting Stability: Think of the $C-F$ bond as a tiny, super-strong anchor. Its bond energy is remarkably high, much greater than that of $C-Cl$ or $C-Br$. This means that by adding more fluorine atoms, we make the molecule much more robust and less susceptible to being broken down too quickly by the liver. It's like giving our medication a longer lifespan in the body, which can be very beneficial!
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