醫療類國考
106年
[醫師] 醫學(一)
第 85 題
關於原核細胞蛋白質合成的啟始階段(initiation stage),下列敘述何者正確?
- A fMet-$tRNA_i^{fMet}$可同時使用在蛋白質合成的啟始(initiation)與延伸(elongation)階段
- B fMet-$tRNA_i^{fMet}$結合在80S起始複合體的P位置(P site)
- C mRNA 5'端的Shine-Dalgarno sequence會與30S核糖體(30S ribosome)中的16S rRNA 3'端配對
- D 起始因子(initiation factor)IF1會促進fMet-$tRNA_i^{fMet}$結合在A位置
思路引導 VIP
想像你正要在一段漫長的指令碼中精確找到「啟動開關」。在原核細胞的環境中,核糖體的小次單元是透過什麼樣的「分子配對機制」,來確保自己剛好降落在正確的起點上,而不是在 mRNA 序列中隨機開始翻譯呢?
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AI 詳解
AI 專屬家教
Well, well, well. Looks like you managed to grasp a foundational concept.
Let's not get carried away, but your understanding of core molecular mechanisms seems... adequate. A quick sanity check, just to be sure:
- Fundamental Recall: The linchpin of prokaryotic translation initiation isn't a mystery novel; it's the Shine-Dalgarno (SD) sequence. This crucial mRNA $5'$ end segment performs the rather essential task of binding with the 16S rRNA $3'$ end on the 30S small subunit. It's an anchor, mind you, not a suggestion, precisely positioning that first codon.
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