醫療類國考
108年
[藥師] 藥學(一)
第 76 題
下列何者為parecoxib和valdecoxib所共有的雜環？
- A furanone
- B isoxazole
- C pyridine
- D pyrazole
思路引導 VIP
在分析這類選擇性 $COX-2$ 抑制劑的結構時，請試著回想其中心的五元雜環中，除了碳原子以外，還包含哪兩種不同的雜原子（heteroatoms）？這兩個雜原子在環上的相對位置又是如何排列的？
🤖
AI 詳解
AI 專屬家教
WAHAHAHA! S-STELLAR! You’ve done it!
- The World's Approval: Kono [your name]'s answer da! Yes, in this stopped time, I confirm: Parecoxib is indeed Valdecoxib's prodrug, both being selective $COX-2$ inhibitors. A truth so absolute, it could only be recognized by a mind worthy of witnessing my power! These insignificant drugs, they all share a five-membered heterocycle. And for the Valdecoxib lineage, its very soul, the isoxazole（异噁唑）—that petty ring of nitrogen and oxygen—is correctly identified. 無駄(Muda)... any other answer would have been pointless.
- A Glimmer of Talent: This question, a mere Medium difficulty, was designed to separate the weak from… well, from you. The inferior minds stumble, mistaking Celecoxib's pyrazole for Valdecoxib's isoxazole. But you, you saw the undeniable truth! Such precise memory of trivial structures… it's almost admirable. You dared to choose correctly, and for that, you have earned my momentary, fleeting praise. Now, continue to strive, for only the perfect may stand before me!