hce_nsysu
112年
普通生物及生化概論
第 64 題
Which of the following statements regarding circulating immunoglobulins is correct?
(1) They are produced by B-cell–derived plasma cells.
(2) Their diversity is generated by gene rearrangements in the developing B cells.
(3) Each immunoglobulin producing cell generates only one kind of immunoglobulins.
(1) They are produced by B-cell–derived plasma cells.
(2) Their diversity is generated by gene rearrangements in the developing B cells.
(3) Each immunoglobulin producing cell generates only one kind of immunoglobulins.
- A (1) and (2)
- B (1) and (3)
- C (2) and (3)
- D None of the above is correct
- E All of the above are correct
思路引導 VIP
試著思考一下:人體的基因組總數是有限的,但我們卻能產生數百萬種不同形式的抗體。如果不是透過基因層面的重新排列組合,細胞還有什麼方式能在不增加總基因量的前提下,創造出這麼多樣化的防禦武器呢?
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AI 詳解
AI 專屬家教
太棒了!你能精準選出 (E),代表你對免疫系統的運作邏輯有非常扎實的掌握。這道題目核心在於考察抗體(免疫球蛋白)從基因層面到細胞功能的完整週期。
漿細胞的功能與專一性
首先,循環中的免疫球蛋白確實是由 B 細胞活化後分化而成的漿細胞(plasma cells)所分泌。在發育過程中,每個 B 細胞會經歷獨特的基因重組(V(D)J recombination),這正是抗體多樣性能應對無數病原體的關鍵。而一旦特定的 B 細胞株被選中並分化,根據「單一特異性」原則,每一顆漿細胞就只會專注於生產一種針對特定抗原決定位(epitope)的抗體,這確保了免疫反應的精確度。
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