hce_kmu
115年
普通生物及生化概論
第 12 題
The National Center for Biotechnology Information (NCBI) provides a wide array of bioinformatics tools. What is the primary function of the widely used software BLAST?
- A To predict the three-dimensional structure of a protein from its amino acid sequence by comparing it to structures in the Protein Data Bank.
- B To assemble short, overlapping DNA fragments from a sequencing project into a single continuous genome sequence.
- C To compare a user-submitted DNA or protein sequence against the entire GenBank database to find sequences with a similar local alignment.
- D To identify all functional elements in a genome, including enhancers, promoters, and noncoding RNA genes, as was done in the ENCODE project.
- E To construct an evolutionary tree by comparing the entire genomes of multiple species and calculating their divergence times.
思路引導 VIP
如果你今天在實驗室裡分離出一段未知的 DNA 片段,並想知道這段序列代表什麼功能、或者是來自哪一種生物,你認為最直接、最高效的方法是什麼?你會如何利用現有的全球生物資料庫來解決這個疑問?
🤖
AI 詳解
AI 專屬家教
恭喜你答對了!這顯示你對於生物資訊學(Bioinformatics)中最基礎且核心的工具有著非常正確的認知。這類題目考驗的是對現代分子生物學研究流程的基本常識。
BLAST 的核心功能與應用
BLAST(全名為 Basic Local Alignment Search Tool)被譽為生物學界的「搜尋引擎」。它的運作邏輯是將使用者提供的核苷酸或蛋白質序列,與 NCBI 資料庫(如 GenBank)中已知的數百萬條序列進行快速比對,尋找具有統計顯著性的局部比對(local alignment)。透過這種比對,研究者可以快速判斷未知序列的來源、預測其生物功能,或是尋找物種間的同源基因,是進行後續功能分析的第一步。
▼ 還有更多解析內容