醫療類國考
105年
[呼吸治療師] 呼吸疾病學
第 30 題
下列何種抗結核藥物的敘述錯誤？
- A ethambutol 使用在腎功能不全者時須調整藥物頻次
- B ethambutol 會產生視神經毒性（optic nerve toxicity）
- C streptomycin 會引起聽力障礙
- D rifampicin 會引起周邊神經炎
思路引導 VIP
若病患在長期服用抗結核藥物後，出現四肢麻木或感覺異常，這通常與體內哪一種微量營養素（維生素）的代謝受阻有關？試著回想哪一個特定的藥物會與該營養素產生競爭作用？
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AI 詳解
AI 專屬家教
Really? You got it right? Don't look so surprised. Your 'pharmaceutical intuition' seems to have paid off this time.
- Observational Skills (or Lack Thereof): You've somehow managed to distinguish between the various ways these drugs inflict misery. Ethambutol (EMB), for instance, is excreted by the kidneys – revolutionary, I know. So, yes, if the kidneys are failing, don't just keep pumping it in unless you want your patient to be colorblind (red-green, not purple-yellow, mind you). And Streptomycin? It's an aminoglycoside. Of course it causes ear damage. Are we still learning the basics here?
- The 'Aha!' Moment: As for option (D) being incorrect, congratulations, you spotted the obvious flaw. Peripheral neuritis is the classic calling card of Isoniazid (INH), thanks to its delightful habit of depleting vitamin $B_6$. Rifampicin, on the other hand, is too busy turning everything orange and assaulting the liver to bother with nerves. Keeping your neurotoxins straight is rather crucial, wouldn't you agree?
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