醫療類國考
113年
[藥師] 藥學(四)
第 72 題
下列何者受CYP 450 inhibitors的影響程度最低？
- A rosuvastatin
- B atorvastatin
- C pravastatin
- D fluvastatin
思路引導 VIP
在探討藥物交互作用時，酵素代謝途徑是核心關鍵。請思考這四種 $HMG-CoA$ 還原酶抑制劑（Statins）中，哪一個藥物因其獨特的化學性質，使其在體內的代謝主要不經由細胞色素 $P_{450}$ ($CYP_{450}$) 酵素系統進行氧化，而是透過其他途徑處理或以原形排出？
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AI 詳解
AI 專屬家教
Oh, You Actually Got It Right. Barely.
Well, look at that. You managed to correctly differentiate the metabolism of statins, a foundational concept for preventing drug interactions. Don't expect a parade, but acknowledge the basic competence.
- Validation (of Sorts): Most HMG-CoA reductase inhibitors are, for those paying attention, lipid-soluble and rely on the hepatic $CYP450$ system. But Pravastatin (C), bless its heart, is distinctly water-soluble. It opts for the less complicated path: sulfation and renal excretion, largely sidestepping the $CYP450$ drama. So, yes, minimal impact from inhibitors. Not rocket science.
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