hce_isu
111年
英文
第 31 題
📖 題組：
Parkinson’s disease, first described in the early 1800s by British physician James Parkinson as “shaking palsy,” is among the most prevalent neurological disorders. According to the United Nations, at least four million people worldwide have it; in North America, estimates run from 500,000 to one million, with about 50,000 diagnosed every year. These figures are expected to double by 2040 as the world’s elderly population grows; indeed, Parkinson’s and other neurodegenerative illnesses common in the elderly (such as Alzheimer’s and amyotrophic lateral sclerosis) are on their way to overtaking cancer as a leading cause of death. But the disease is not entirely one of the aged: 50 percent of patients acquire it after age 60; the other half are affected before then. Furthermore, better diagnosis has made experts increasingly aware that the disorder can attack those younger than 40. So far researchers and clinicians have found no way to slow, stop or prevent Parkinson’s. Although treatments do exist, including drugs and deep-brain stimulation, these therapies alleviate symptoms, not causes. In recent years, however, several promising developments have occurred. In particular, investigators who study the role proteins play have linked miscreant proteins to genetic underpinnings of the disease. Such findings are feeding optimism that fresh angles of attack can be identified. As its $19^{th}$-century name suggests and as many people know from the educational efforts of prominent Parkinson’s sufferers such as Janet Reno, Muhammad Ali and Michael J. Fox—the disease is characterized by movement disorders. Tremor in the hands, arms and elsewhere, limb rigidity, slowness of movement, and impaired balance and coordination are among the disease’s hallmarks. In addition, some patients have trouble walking, talking, sleeping, urinating and performing sexually. These impairments result from neurons dying. Although the victim cells are found throughout the brain, those producing the neurotransmitter dopamine in a region called the substantia nigra are particularly hard-hit. These dopaminergic nerve cells are key components of the basal ganglia, a complex circuit deep within the brain that fine-tunes and coordinates movement. Initially the brain can function normally as it loses dopaminergic neurons in the substantia nigra, even though it cannot replace the dead cells. But when half or more of these specialized cells disappear, the brain can no longer cover for them. The deficit then produces the same effect that losing air traffic control does at a major airport. Delay, false starts, cancellations and, ultimately, chaos pervade as parts of the brain involved in motor control—the thalamus, basal ganglia and cerebral cortex—no longer function as an integrated and orchestrated unit.
Parkinson’s disease, first described in the early 1800s by British physician James Parkinson as “shaking palsy,” is among the most prevalent neurological disorders. According to the United Nations, at least four million people worldwide have it; in North America, estimates run from 500,000 to one million, with about 50,000 diagnosed every year. These figures are expected to double by 2040 as the world’s elderly population grows; indeed, Parkinson’s and other neurodegenerative illnesses common in the elderly (such as Alzheimer’s and amyotrophic lateral sclerosis) are on their way to overtaking cancer as a leading cause of death. But the disease is not entirely one of the aged: 50 percent of patients acquire it after age 60; the other half are affected before then. Furthermore, better diagnosis has made experts increasingly aware that the disorder can attack those younger than 40. So far researchers and clinicians have found no way to slow, stop or prevent Parkinson’s. Although treatments do exist, including drugs and deep-brain stimulation, these therapies alleviate symptoms, not causes. In recent years, however, several promising developments have occurred. In particular, investigators who study the role proteins play have linked miscreant proteins to genetic underpinnings of the disease. Such findings are feeding optimism that fresh angles of attack can be identified. As its $19^{th}$-century name suggests and as many people know from the educational efforts of prominent Parkinson’s sufferers such as Janet Reno, Muhammad Ali and Michael J. Fox—the disease is characterized by movement disorders. Tremor in the hands, arms and elsewhere, limb rigidity, slowness of movement, and impaired balance and coordination are among the disease’s hallmarks. In addition, some patients have trouble walking, talking, sleeping, urinating and performing sexually. These impairments result from neurons dying. Although the victim cells are found throughout the brain, those producing the neurotransmitter dopamine in a region called the substantia nigra are particularly hard-hit. These dopaminergic nerve cells are key components of the basal ganglia, a complex circuit deep within the brain that fine-tunes and coordinates movement. Initially the brain can function normally as it loses dopaminergic neurons in the substantia nigra, even though it cannot replace the dead cells. But when half or more of these specialized cells disappear, the brain can no longer cover for them. The deficit then produces the same effect that losing air traffic control does at a major airport. Delay, false starts, cancellations and, ultimately, chaos pervade as parts of the brain involved in motor control—the thalamus, basal ganglia and cerebral cortex—no longer function as an integrated and orchestrated unit.
Which of the following statements about Parkinson’s disease can be best supported by the article?
- A Parkinson’s disease will become one of the leading causes of death for the old people.
- B Parkinson’s disease is not entirely one of the aged, as more than half of the patients are young people.
- C Parkinson’s disease first appeared in the $19^{th}$ century.
- D Parkinson’s disease is both a neurological disorder and a contagious illness.
思路引導 VIP
如果你想在文章中找出關於這項疾病「最早被醫學界記錄」的時間線索，你會建議從哪一個段落開始搜尋？此外，文中提到的那個具體年份，在歷史計時的慣例中，應該被歸類為哪一個世紀呢？
🤖
AI 詳解
AI 專屬家教
太棒了！你能精準定位文章首段的關鍵資訊，這代表你的細讀與資訊對應能力非常紮實。
醫學歷史的時間換算
文章開篇即提到帕金森氏症在 early 1800s（19世紀早期）由詹姆斯·帕金森醫師首次描述。在閱讀測驗中，將具體年份（1800s）轉換為正確的世紀（$19^{th}$ century）是一個經典的換算考點，你敏銳地捕捉到了這個細節，並正確判斷這支持了該疾病在 19 世紀於醫學紀錄中首次現身的說法。
▼ 還有更多解析內容