hce_nsysu
113年
英文
第 42 題
📖 題組：
More than 35,000 people die each year in the US alone from antimicrobial resistant infections. With novel treatments in short supply, scientists plan to boost available therapies to target antimicrobial resistance. In a paper published in PNAS, researchers used the power of light to give antibiotics a fighting chance. Light interacts with chemicals called photosensitizers to produce toxic reactive oxygen species. Unlike many antibiotics, photosensitizers can sneak past bacterial defenses. For example, it was found that light, plus the photosensitizer curcumin, a chemical found in turmeric, potentiated antibiotic efficacy. In their new study, Dr. Bagnato and his team found that they needed to expose drug-resistant strains of Staphylococcus aureus to high doses of different antibiotics to curb its growth. However, when Bagnato added the curcumin and shone light on the bacteria, a lower dose sufficed. Still, the effects were limited. For most strains, the effects were temporary; the team observed a recurrence in resistance after only a few cycles of bacterial growth. Bagnato emphasized the need for alternative therapies. “Infection does not need one type of weapon; it needs a whole arsenal,” said Bagnato.
More than 35,000 people die each year in the US alone from antimicrobial resistant infections. With novel treatments in short supply, scientists plan to boost available therapies to target antimicrobial resistance. In a paper published in PNAS, researchers used the power of light to give antibiotics a fighting chance. Light interacts with chemicals called photosensitizers to produce toxic reactive oxygen species. Unlike many antibiotics, photosensitizers can sneak past bacterial defenses. For example, it was found that light, plus the photosensitizer curcumin, a chemical found in turmeric, potentiated antibiotic efficacy. In their new study, Dr. Bagnato and his team found that they needed to expose drug-resistant strains of Staphylococcus aureus to high doses of different antibiotics to curb its growth. However, when Bagnato added the curcumin and shone light on the bacteria, a lower dose sufficed. Still, the effects were limited. For most strains, the effects were temporary; the team observed a recurrence in resistance after only a few cycles of bacterial growth. Bagnato emphasized the need for alternative therapies. “Infection does not need one type of weapon; it needs a whole arsenal,” said Bagnato.
42. What is the primary focus of the study mentioned in the news?
- A Developing new antibiotics
- B Using the light in antibiotic treatment
- C Investigating bacterial defenses
- D Identifying drug-resistant strains of bacteria
- E Testing the effects of turmeric on bacteria
思路引導 VIP
當文中提到科學家為了對抗抗藥性細菌，特別引入了一種能與化學物質互動、並產生毒性物質來突破細菌防禦的「外部能量形式」時，你認為這項實驗設計中最重要的創新媒介是什麼？
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AI 詳解
AI 專屬家教
太棒了！你能精準掌握文章的核心主旨，選出 (B) 確實展現了你優異的閱讀理解能力。這題的關鍵在於辨識研究中的「核心變因」與「治療手段」。
光動力療法的核心機制
文章開頭便破題提到研究人員利用「光的力量（power of light）」賦予抗生素新的生機。文中詳細解釋了光如何與光感劑（photosensitizers）互動，進而產生能對付細菌的活性氧。雖然實驗中使用了薑黃素（curcumin），但那只是作為輔助的媒介，真正的治療創新在於「光」的介入，使得在面對抗藥性金黃色葡萄球菌（Staphylococcus aureus）時，僅需低劑量的抗生素便足以產生療效。
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